Targeted therapy for malignant ocular melanomas
نویسندگان
چکیده
منابع مشابه
Targeted Therapy for BRAF Malignant Astrocytoma
Running title: Targeting BRAF V600E in Malignant Astrocytoma We declare no conflict of interest (or relationship that would be suspected of constituting conflicts) at the time of submission. Author manuscripts have been peer reviewed and accepted for publication but have not yet been edited. Malignant astrocytoma (MA) is the most common histopathologic subclassification for primary central nerv...
متن کاملCataract Avoidance With Proton Therapy in Ocular Melanomas.
Purpose The lens is a radiosensitive organ. Any dose of cephalic irradiation can give rise to radiation-induced cataracts. Contrary to other forms of radiotherapy, proton therapy (PT) can spare all or part of the lens due to accurate dose deposition. We investigated whether a lens-sparing approach was relevant to avoid cataracts in uveal melanoma patients. Methods Patients were referred for P...
متن کاملHuman malignant melanomas express receptors for luteinizing hormone releasing hormone allowing targeted therapy with cytotoxic luteinizing hormone releasing hormone analogue.
Cytotoxic analogue of luteinizing hormone releasing hormone (LHRH), AN-207, binds with high affinity to LHRH receptors and can be targeted to tumors expressing these receptors. We investigated the expression of LHRH receptors in surgical specimens of human malignant melanoma and evaluated the effects of AN-207 in models of human melanoma. Human melanoma specimens derived from primary tumors or ...
متن کاملCancer Therapy: Preclinical Targeted Therapy for BRAF Malignant Astrocytoma
Purpose: Malignant astrocytomas (MA) are aggressive central nervous system tumors with poor prognosis. Activating mutation of BRAF (BRAF) has been reported in a subset of these tumors, especially in children. We have investigated the incidence of BRAF in additional pediatric patient cohorts and examined the effects of BRAF blockade in preclinical models of BRAF and wild-type BRAF MA. Experiment...
متن کاملHistopathological findings concerning ocular melanomas.
Ocular melanoma is rare in clinical practice. In this study, we present three cases of ocular melanoma surgically removed in the Department of Ophthalmology of the Emergency University Hospital of Bucharest, Romania, and diagnosed in the Department of Pathology of the same hospital using conventional histopathological techniques and immunohistochemical tests.
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Annals of Eye Science
سال: 2021
ISSN: 2520-4122
DOI: 10.21037/aes-20-101